circRNA basic information
circBase ID: -
Name: hsa_circ_NUP98
Synonym: -
Host Gene: hsa-miR-567
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human renal normal cells (293K), RCC cells (ACHN, 786_O, Caki_1)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PRDX3
Associated microRNA: hsa-miR-567
Biological function: Silencing of circSMC3 inhibited the proliferation and promoted the apoptosis
Molecular mechanism: down-regulating of PRDX3 via up-regulation of hsa-miR-567
Survival: poor
Supported No.:
 1
Description:

silencing of circ NUP98 inhibited RCC progression by down-regulating of PRDX3 via up-regulation of miR-567. Furthermore, STAT3 was identified as an inducer of circ NUP98 in RCC cells. CircNUP98 acts as an oncogene by a novel STAT3/circ NUP98/miR-567/PRDX3 axis, which may provide a potential biomarker and therapeutic target for the treatment of RCC.
Other information
Title:

A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma.

Journal: J Cell Mol Med
Published: 2020/7/31
PubMed ID: 32729669