circRNA basic information
circBase ID: hsa_circ_0000073
Name: hsa_circ_OMA1
Synonym: -
Host Gene: hsa-miR-145-5p, hsa-miR-151-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteoblast cells (hFOB 1.19), OS cells (MG63, 143B, U2OS, HOS), HEK293 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NRAS
Associated microRNA: hsa-miR-145-5p, hsa-miR-151-3p
Biological function: facilitated the proliferation, migration, invasion and MTX resistance of OS cells
Molecular mechanism: through the inhibition of hsa-miR-145-5p and hsa-miR-151-3p-mediated downregulation of NRAS
Survival: -
Supported No.:
 4
Description:

hsa_circ_0000073 facilitated the proliferation, migration, invasion and MTX resistance of OS cells through the inhibition of miR-145-5p and miR-151-3p-mediated downregulation of NRAS.
Other information
Title:

Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS.

Journal: Aging (Albany NY)
Published: 2020/7/25
PubMed ID: 32706759