circRNA basic information
circBase ID: -
Name: hsa_circ_FANCL
Synonym: -
Host Gene: hsa-miR-337-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A172, U251, SHG44, LN229, NHA
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: HMGB1
Associated microRNA: hsa-miR-337-3p
Biological function: Down-regulated circFANCL induced the proliferation inhibition, cell cycle arrest and apoptosis promotion of glioma cells in vitro, and inhibited tumor growth in vivo
Molecular mechanism: targeted hsa-miR-337-3p to regulate HMGB1
Survival: poor
Supported No.:
 1
Description:

Through the illustration of oncogenic function of circFANCL in glioma by the miR-337-3p/HMGB1 axis, we believed that circFANCL might be a great target in the early diagnosis and late treatment of glioma.
Other information
Title:

Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis.

Journal: Minerva Med
Published: 2020/7/21
PubMed ID: 32683852