circRNA basic information
circBase ID: -
Name: hsa_circ_AGFG1
Synonym: -
Host Gene: hsa-miR-4262, hsa-miR-185-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human colon epithelial cell line (NCM460), CRC cell lines (SW480, HCT116, SW620, HT-29)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YY1/CTNNB1
Associated microRNA: hsa-miR-4262, hsa-miR-185-5p
Biological function: CircAGFG1 silencing significantly suppressed cell proliferation, migration, invasion, and stemness, while promoted cell apoptosis in CRC
Molecular mechanism: sponged hsa-miR-4262 and hsa-miR-185-5p to upregulate YY1 expression
Survival: -
Supported No.:
 1
Description:

circAGFG1 modulated YY1/CTNNB1 axis to drive metastasis and stemness in CRC by sponging miR-4262 and miR-185-5p.
Other information
Title:

CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1.

Journal: Cell Death Dis
Published: 2020/7/19
PubMed ID: 32681092