circRNA basic information
circBase ID: hsa_circ_0026134
Name: hsa_circ_TUBA1C
Synonym: -
Host Gene: hsa-miR-127-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Liver cancer cell lines (HepG2, HepaRG, LM3, SK-Hep1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TRIM25 and IGF2BP3
Associated microRNA: hsa-miR-127-5p
Biological function: promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion
Molecular mechanism: sponging hsa-miR-127-5p
Survival: -
Supported No.:
 2
Description:

Down-regulation of hsa_circ_0026134 suppressed TRIM25- and IGF2BP3-mediated HCC cell proliferation and invasion via promotion of miR-127-5p expression, which have been confirmed by luciferase reporter assay.

Other information
Title:

Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p.

Journal: Biosci Rep
Published: 2020/7/11
PubMed ID: 32648571