circRNA basic information
circBase ID: hsa_circ_0007334
Name: hsa_circ_MBOAT2
Synonym: -
Host Gene: hsa-miR-1271-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PCa cell lines (PC-3, DU145, VCaP, LNCaP, C4-2B), human normal prostate epithelial cell line (RWPE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: mTOR
Associated microRNA: hsa-miR-1271-5p
Biological function: promotes proliferation and metastasis
Molecular mechanism: through hsa-miR-1271-5p/mTOR axis-mediated activation of the PI3K/Akt pathway
Survival: poor
Supported No.:
 1
Description:

circMBOAT2 overexpression upregulated the expression of mTOR by acting as a decoy for miR-1271-5p, resulting in the activation of the PI3K/Akt pathway, ultimately promoting the progression of PCa. Importantly, application of an inhibitor of mTOR significantly antagonized circMBOAT2-mediated PCa tumorigenesis in vivo. circMBOAT2 promotes proliferation and metastasis of PCa through miR-1271-5p/mTOR axis-mediated activation of the PI3K/Akt pathway.
Other information
Title:

Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis.

Journal: Aging (Albany NY)
Published: 2020/7/10
PubMed ID: 32645691