circRNA basic information
circBase ID: -
Name: hsa_circ_NRIP1
Synonym: -
Host Gene: hsa-miR-182
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human gastric cancer cell lines (MGC-803, AGS, HGC-27, SGC-7901), normal human gastric mucosal epithelial cell (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1
Associated microRNA: hsa-miR-182
Biological function: Knockdown of circNRIP1 suppressed cell migration and invasion, arrested cell cycle at G0-G1 phase and promoted apoptosis in gastric cancer cells.
Molecular mechanism: increasing hsa-miR-182 and decreasing ROCK1
Survival: poor
Supported No.:
 6
Description:

Silence of circNRIP1 inhibited progression of gastric cancer by increasing miR-182 and decreasing ROCK1, providing a novel target for the treatment of gastric cancer.
Other information
Title:

Down-Regulation of circNRIP1 Promotes the Apoptosis and Inhibits the Migration and Invasion of Gastric Cancer Cells by miR-182/ROCK1 Axis.

Journal: Onco Targets Ther
Published: 2020/7/9
PubMed ID: 32636647