circRNA basic information
circBase ID: hsa_circ_0005394
Name: hsa_circ_ZC3H7A
Synonym: -
Host Gene: hsa-miR-507, hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cells (Sk-Hep-1, SMMC7721, HCCLM3, Huh-7, HepG2), normal cell line (L02)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F3 and CXCL6
Associated microRNA: hsa-miR-507, hsa-miR-515-5p
Biological function: facilitated HCC growth and invasion
Molecular mechanism: regulating hsa-miR-507/E2F3 and hsa-miR-515-5p/CXCL6 signaling pathways
Survival: poor
Supported No.:
 1
Description:

Rescue assay indicated that circ_0005394 facilitated HCC growth and invasion by regulating miR-507/E2F3 and miR-515-5p/CXCL6 signaling pathways. This study uncovered an important role of circ_0005394 in regulating HCC progression, providing a novel perspective for clarifying its pathogenesis.
Other information
Title:

A Novel Circular RNA, circ_0005394, Predicts Unfavorable Prognosis and Contributes to Hepatocellular Carcinoma Progression by Regulating miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways.

Journal: Onco Targets Ther
Published: 2020/7/9
PubMed ID: 32636641