circRNA basic information
circBase ID: -
Name: hsa_circ_DDX17
Synonym: -
Host Gene: hsa-miR-605
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Breast cancer cell lines (MCF-7, MCF-10A, BT474, BT549, HCC2218)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK1 and p21
Associated microRNA: hsa-miR-605
Biological function: inhibiting proliferation and promoting apoptosis
Molecular mechanism: as a sponge of hsa-miR-605
Survival: better
Supported No.:
 1
Description:

We identified the downregulation of circDDX17 in breast cancer, and circDDX17 acted as a tumour suppressor by inhibiting proliferation and promoting apoptosis through its function as a sponge of miR-605 in breast cancer, indicating that it serves as a potential biomarker and a therapeutic target for breast cancer.
Other information
Title:

CircDDX17 acts as a competing endogenous RNA for miR-605 in breast cancer progression.

Journal: Eur Rev Med Pharmacol Sci
Published: 2020/7/8
PubMed ID: 32633371