circRNA basic information
circBase ID: hsa_circ_0082003
Name: hsa_circ_MET
Synonym: -
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (A549, 95C, 95D, HBE, NCI-H1299, NCI-H460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCL3
Associated microRNA: hsa-miR-145-5p
Biological function: promotes NSCLC cell proliferation, metastasis, and immune evasion
Molecular mechanism: regulating the hsa-miR-145-5p/CXCL3 axis
Survival: poor
Supported No.:
 1
Description:

circMET acts as a miR-145-5p sponge to upregulate CXCL3 expression. Collectively, circMET regulates the miR-145-5p/CXCL3 axis and serves as a novel, promising diagnostic and prognostic biomarker in patients with NSCLC.
Other information
Title:

circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis.

Journal: Aging (Albany NY)
Published: 2020/7/3
PubMed ID: 32614785