circRNA basic information
circBase ID: -
Name: hsa_circ_NOL10
Synonym: -
Host Gene: hsa-miR-135a-5p, hsa-miR-135b-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC cells (SW620, SW480, LOVO, HCT116), human colonic epithelial cells (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: KLF9
Associated microRNA: hsa-miR-135a-5p, hsa-miR-135b-5p
Biological function: constrained proliferation, cell-cycle progression, migration, and invasion of CRC cells
Molecular mechanism: sponging hsa-miR-135a-5p and hsa-miR-135b-5p
Survival: better
Supported No.:
 1
Description:

circNOL10 impeded CRC development by mediating proliferation, cell cycle, migration, and invasion by sponging miR-135a-5p and miR-135b-5p, which provided new understanding for CRC treatment.
Other information
Title:

CircNOL10 Acts as a Sponge of miR-135a/b-5p in Suppressing Colorectal Cancer Progression via Regulating KLF9.

Journal: Onco Targets Ther
Published: 2020/7/2
PubMed ID: 32606737