circRNA basic information
circBase ID: hsa_circ_0079586
Name: hsa_circ_IGF2BP3
Synonym: -
Host Gene: hsa-miR-183-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GM cell lines (U87MG, U251, U118, LN229H4), NHA cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MDM4
Associated microRNA: hsa-miR-183-5p
Biological function: increased the proliferation, migration and invasion
Molecular mechanism: interaction with the hsa-miR-183-5p/MDM4 axis
Survival: poor
Supported No.:
 2
Description:

circ_0079586 was found to be up-regulated in GM that increased the proliferation, migration and invasion in GM cells via interaction with the miR-183-5p/MDM4 axis. We anticipate that our study would provide newer insights into the mechanism and treatment of GM.
Other information
Title:

Elevation in the Expression of circ_0079586 Predicts Poor Prognosis and Accelerates Progression in Glioma via Interactions with the miR-183-5p/MDM4 Signaling Pathway.

Journal: Onco Targets Ther
Published: 2020/7/2
PubMed ID: 32606734