circRNA basic information
circBase ID: hsa_circ_0000936
Name: hsa_circ_SHKBP1
Synonym: -
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HUVECs cell lines (AGS), HEK-293_T, HGC27, BGC823, MGC803, GES1
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: HUR/VEGF
Associated microRNA: hsa-miR-582-3p
Biological function: promoted GC cell proliferation, migration, invasion and angiogenesis
Molecular mechanism: sponged hsa-miR-582-3p to increase HUR expression, enhancing VEGF mRNA stability
Survival: -
Supported No.:
 1
Description:

exosomal circSHKBP1 regulates the miR-582-3p/HUR/VEGF pathway, suppresses HSP90 degradation, and promotes GC progression. circSHKBP1 is a promising circulating biomarker for GC diagnosis and prognosis and an exceptional candidate for further therapeutic exploration.
Other information
Title:

Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.

Journal: Mol Cancer
Published: 2020/7/1
PubMed ID: 32600329