circRNA basic information
circBase ID: -
Name: hsa_circ_UHRF1
Synonym: -
Host Gene: hsa-miR-449c-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (HepG2, HCCLM3, SMMC-7721, Huh 7, PLC/PRF/5, Hep3B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TIM-3
Associated microRNA: hsa-miR-449c-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 2
Description:

Exosomal circUHRF1 is predominantly secreted by HCC cells and contributes to immunosuppression by inducing NK cell dysfunction in HCC. CircUHRF1 may drive resistance to anti-PD1 immunotherapy, providing a potential therapeutic strategy for patients with HCC.
Other information
Title:

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma.

Journal: Mol Cancer
Published: 2020/7/1
PubMed ID: 32593303