circRNA basic information
circBase ID: hsa_circ_0003949
Name: hsa_circ_PTN
Synonym: -
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (Hep3B, MHCC97-L, MHCC97-H, SMMC-7721), normal liver cell lines (L02, THLE-3, 293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ErbB/PI3K
Associated microRNA: hsa-miR-326
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circPTN acted as a sponge through interacting with miR-326. Overexpression of miR-326 could rescue the cell proliferation inhibition and ErbB/PI3K downregulation in HCC cells by circPTN. Besides, the effects of miR-326 on HCC were missing when circPTN binding sites were mutated.
Other information
Title:

CircRNA-PTN Sponges miR-326 to Promote Proliferation in Hepatocellular Carcinoma.

Journal: Onco Targets Ther
Published: 2020/6/26
PubMed ID: 32581550