circRNA basic information
circBase ID: hsa_circ_0074027
Name: hsa_circ_PITX1
Synonym: -
Host Gene: hsa-miR-335-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human bronchial epithelial cell line (BEAS-2B), NSCLC cell lines (H358, H1299, H1581, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CUL4B
Associated microRNA: hsa-miR-335-5p
Biological function: Circ_0074027 knockdown suppressed cell viability, cell cycle process, and colony formation and promoted apoptosis in NSCLC cells in vitro and inhibited tumor growth in vivo
Molecular mechanism: regulating hsa-miR-335-5p/CUL4B axis.
Survival: -
Supported No.:
 3
Description:

Circ_0074027 facilitated NSCLC cell progression through regulating miR-335-5p/CUL4B axis.
Other information
Title:

Circ_0074027 Contributes to Non-Small Cell Lung Cancer Progression by Upregulating CUL4B Expression Through miR-335-5p.

Journal: Cancer Biother Radiopharm
Published: 2020/6/26
PubMed ID: 32580576