circRNA basic information
circBase ID: hsa_circ_0101145
Name: -
Synonym: -
Host Gene: hsa-miR-548c-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HCC cell lines (HepG2, SMMC7721, Huh-7, Sk-Hep-1), normal human liver cell line (L02)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: LAMC2
Associated microRNA: hsa-miR-548c-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

hsa_circ_0101145 silencing suppressed HCC progression by functioning as an miR-548c-3p sponge to enhance LAMC2 expression. Therefore, hsa_circ_0101145 could be an HCC treatment target.
Other information
Title:

Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis.

Journal: Aging (Albany NY)
Published: 2020/6/20
PubMed ID: 32554866