circRNA basic information
circBase ID: hsa_circ_0000517
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: hsa-miR-1296-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal liver cells (THLE-2), HCC cells (SNU-387, Huh7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TXNDC5
Associated microRNA: hsa-miR-1296-5p
Biological function: Silencing of circ_0000517 suppressed HCC cell viability and colony formation and promoted cell cycle arrest and apoptosis in vitro and hampered tumor growth in vivo.
Molecular mechanism: upregulating TXNDC5 through sponging hsa-miR-1296-5p
Survival: -
Supported No.:
 6
Description:

Circ_0000517 accelerated HCC progression by upregulating TXNDC5 through sponging miR-1296-5p.
Other information
Title:

Circ_0000517 Contributes to Hepatocellular Carcinoma Progression by Upregulating TXNDC5 via Sponging miR-1296-5p.

Journal: Cancer Manag Res
Published: 2020/6/12
PubMed ID: 32523376