circRNA basic information
circBase ID: hsa_circ_0013290
Name: hsa_circ_AGL
Synonym: circ_0013290
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (Hep3B, Huh-7), human immortal liver cells (THLE-2), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MMP16
Associated microRNA: hsa-miR-139-5p
Biological function: Matrine treatment inhibited HCC cell proliferation, invasion and tube formation but induced cell apoptosis, accompanied by the decrease of CyclinD1 and N-cadherin expression
Molecular mechanism: circ_0013290/hsa-miR-139-5p/MMP16 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Matrine inhibited HCC cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway, suggesting that Matrine is a potential therapeutic agent for HCC.
Other information
Title:

Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway.

Journal: Histol Histopathol
Published: 2023/1/4
PubMed ID: 36594718