circRNA basic information
circBase ID: hsa_circ_0003141
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: hsa-miR-1827
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Huh-7, Hep3B2.1-7
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: UBAP2
Associated microRNA: hsa-miR-1827
Biological function: Downregulation of hsa_circ_0003141 suppresses UBAP2 expression, induces apoptosis, and inhibits proliferation and invasion by HCC Huh-7 cells
Molecular mechanism: hsa_circ_0003141/hsa-miR-1827/UBAP2 axis
Survival: poor
Supported No.:
 4
Description:

hsa_circ_0003141 functions as an oncogene in HCC cells, and suggest that the hsa_circ_0003141/miR-1827/UBAP2 axis might represent a novel therapeutic option for the treatment of HCC.
Other information
Title:

Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis.

Journal: Aging (Albany NY)
Published: 2020/5/29
PubMed ID: 32464601