circRNA basic information
circBase ID: hsa_circ_0004214
Name: hsa_circ_AMOTL1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HaCaT, MCF-10A
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: c-myc
Associated microRNA: -
Biological function: promotes tumorigenesis
Molecular mechanism: inducing c-myc nuclear translocation
Survival: -
Supported No.:
 2
Description:

Single-cell inoculations using circ-Amotl1-transfected tumor cells showed a 30-fold increase in proliferative capacity relative to control. this potent tumorigenicity was triggered through interactions between circ-Amotl1 and c-myc.
Other information
Title:

A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.

Journal: Cell Death Differ
Published: 2017/6/18
PubMed ID: 28622299