circRNA basic information
circBase ID: -
Name: -
Synonym: Circ_100565
Host Gene: hsa-miR-506-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (Calu-3, Calu-6, A549, H1299)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-506-3p
Biological function: Silencing of circ_100565 suppressed the proliferation, migration and invasion of NSCLC cells in vitro and reduced the tumor growth of NSCLC in vivo
Molecular mechanism: sponge hsa-miR-506-3p
Survival: -
Supported No.:
 1
Description:

Circ_100565 increased HMGA2 expression to promote proliferation, migration and invasion in NSCLC via absorbing miR-506-3p. Our findings provided a new biomarker for NSCLC therapy.
Other information
Title:

Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p.

Journal: Cancer Cell Int
Published: 2020/5/20
PubMed ID: 32425695