circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-641
 
 
 
Disease basic information
DO ID:
 4947
DO name: cholangiocarcinoma
Disease details: cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: cholangiocyte cell line (HIBEpiC), human CCA cell lines (HCCC-9810, RBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-641
Biological function: promoted the cell proliferation, migration, invasion, and activation of the AKT3/mTOR pathway
Molecular mechanism: Regulating MicroRNA 641
Survival: -
Supported No.:
 2
Description:

CDR1as could bind with miR-641 and accelerate miR-641 degradation, which possibly leads to the upregulation of the relative mRNA levels of AKT3 and mTOR in RBE cells.

Other information
Title:

Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.

Journal: Mol Cell Biol
Published: 2020/5/20
PubMed ID: 32423991