circRNA basic information
circBase ID: -
Name: -
Synonym: hsa-circ-000684
Host Gene: hsa-miR-186
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NCI-87, MGG-803, SGC-7901, BGC-823, BEL-7402, GES-1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: hsa-miR-186
Biological function: knockdown of hsa-circ-000684 or upregulation of miR-186 inhibited GC cell proliferation, migration, invasion, and tube formation in vitro, and reduced the xenograft tumor growth in nude mice
Molecular mechanism: increased the expression of ZEB1 by binding to hsa-miR-186
Survival: -
Supported No.:
 1
Description:

hsa-circ-000684 reduces the miR-186 expression which leads to an increase in the ZEB1 expression and, consequently, promotion of GC progression.
Other information
Title:

Oncogenic circular RNA Hsa-circ-000684 interacts with microRNA-186 to upregulate ZEB1 in gastric cancer.

Journal: FASEB J
Published: 2020/5/11
PubMed ID: 32388910