circRNA basic information
circBase ID: hsa_circ_0086375
Name: hsa_circ_NFIB1
Synonym: -
Host Gene: hsa-miR-486-5p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PDAC cell lines (PANC1, Capan-2, SW1990), human pancreatic ductal endothelial cells (HPDE)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: PIK3R1/VEGF-C axis
Associated microRNA: hsa-miR-486-5p
Biological function: circNFIB1 knockdown promoted lymphangiogenesis and LN metastasis of PDAC both in vitro and in vivo.
Molecular mechanism: functioned as a sponge of hsa-miR-486-5p, and partially reversed the effect of hsa-miR-486-5p
Survival: -
Supported No.:
 1
Description:

circNFIB1 attenuated the oncogenic effect of miR-486-5p and consequently upregulated PIK3R1 expression, which further downregulated VEGF-C expression through inhibition of the PI3K/Akt pathway, and ultimately suppressed lymphangiogenesis and LN metastasis in PDAC.
Other information
Title:

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer.

Journal: Mol Cancer
Published: 2020/5/6
PubMed ID: 32366257