circRNA basic information
circBase ID: hsa_circ_0101874
Name: -
Synonym: circ_0101874
Host Gene: hsa-miR-335-5p
 
 
 
Disease basic information
DO ID:
 3526
DO name: cerebral infarction
Disease details: Ischemic stroke
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: SK-N-SH cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDE4D
Associated microRNA: hsa-miR-335-5p
Biological function: Circ_0101874 knockdown suppressed OGD-enhanced inflammation, cell apoptosis and oxidative stress and promoted OGD-inhibited cell viability and cell proliferation in SK-N-SH cells.
Molecular mechanism: Circ_0101874 directly bound to miR-335-5p, and miR-335-5p inhibition reversed the effects of circ_0101874 knockdown.
Survival: -
Supported No.:
 1
Description:

Circ_0101874 knockdown alleviated OGD-induced neuronal cell injury by suppressing PDE4D via regulating miR-335-5p.
Other information
Title:

Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke.

Journal: J Stroke Cerebrovasc Dis
Published: 2022/10/18
PubMed ID: 36252429