circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 7693
DO name: abdominal aortic aneurysm
Disease details: abdominal aortic aneurysm
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: primary VSMCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: CKAP4
Associated microRNA: hsa-miR-7
Biological function: regulating the proliferation and apoptosis of primary vascular smooth muscle cells
Molecular mechanism: CDR1as/hsa-miR-7/CKAP4 axis
Survival: -
Supported No.:
 1
Description:

CDR1as also decreased caspase 3/7 activity, which was reversed by miR-7 mimics. miR-7 increased the activity of caspase 3/7, which was again reversed by the overexpression of CKAP4. Therefore, CDR1as, miR-7 and CKAP4 may act in the same pathway to regulate VSMC proliferation and apoptosis.
Other information
Title:

CDR1as/miR-7/CKAP4 axis contributes to the pathogenesis of abdominal aortic aneurysm by regulating the proliferation and apoptosis of primary vascular smooth muscle cells.

Journal: Exp Ther Med
Published: 2020/4/30
PubMed ID: 32346440