circRNA basic information
circBase ID: hsa_circ_0000372
Name: hsa_circ_APLP2
Synonym: -
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (SW480, LOVO), normal colon mucosal epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXK1
Associated microRNA: hsa-miR-485-5p
Biological function: circAPLP2 knockdown or miR-485-5p overexpression suppressed cell proliferation, migration, and invasion, whereas it promoted apoptosis in CRC cells
Molecular mechanism: regulating hsa-miR-485-5p/FOXK1
Survival: -
Supported No.:
 1
Description:

circAPLP2 knockdown inhibited CRC progression through regulating miR-485-5p/FOXK1 axis, providing a novel avenue for treatment of CRC.
Other information
Title:

Knockdown of circAPLP2 Inhibits Progression of Colorectal Cancer by Regulating miR-485-5p/FOXK1 Axis.

Journal: Cancer Biother Radiopharm
Published: 2020/4/29
PubMed ID: 32343603