circRNA basic information
circBase ID: -
Name: hsa_circ_CRIM1
Synonym: -
Host Gene: hsa-miR-125b-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BEAS-2B cell line, two LUAC cell line (A549, PC-9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: BTG2
Associated microRNA: hsa-miR-125b-5p
Biological function: suppresses lung adenocarcinoma cell migration, invasion, EMT, and glycolysis
Molecular mechanism: regulating hsa-miR-125b-5p/BTG2 axis
Survival: -
Supported No.:
 2
Description:

CircCRIM1 was lowly expressed in LUAC. Moreover, circCRIM1 functioned as a sponge of miR-125b-5p to improve BTG2 expression, thereby suppressing LUAC development. Our finding indicated that circCRIM1 could be considered as a biomarker and target for the diagnosis and therapy of LUAC patients.
Other information
Title:

Circular RNA circCRIM1 suppresses lung adenocarcinoma cell migration, invasion, EMT, and glycolysis through regulating miR-125b-5p/BTG2 axis.

Journal: Eur Rev Med Pharmacol Sci
Published: 2020/4/25
PubMed ID: 32329853