circRNA basic information
circBase ID: hsa_circ_0002052
Name: hsa_circ_PAPPA
Synonym: -
Host Gene: hsa-miR-382
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OS cell lines, non-cancer cell line (hFOB 1.19), 293T cell line
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: STX6
Associated microRNA: hsa-miR-382
Biological function: silencing of circ-0002052 suppressed proliferation, migration, and invasion of OS cells
Molecular mechanism: modulating hsa-miR-382/STX6 axis
Survival: -
Supported No.:
 5
Description:

circ-0002052, functioning as a sponge for miR-382, enhances the activation of Wnt/beta-catenin mediated by STX6 to stimulate the progression of OS, and circ-0002052 may be an underlying treatment target and a biomarker for prognosis of osteosarcoma.
Other information
Title:

Circular RNA hsa_circ_0002052 promotes osteosarcoma via modulating miR-382/STX6 axis.

Journal: Hum Cell
Published: 2020/4/11
PubMed ID: 32274658