circRNA basic information
circBase ID: -
Name: hsa_circ_VAPA
Synonym: -
Host Gene: hsa-miR-125a
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal colon mucosal epithelial cell line NCM460, CRC cell lines (HCT116, LOVO)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CREB5
Associated microRNA: hsa-miR-125a
Biological function: promote progression, migration, invasion and glycolysis partly
Molecular mechanism: modulating hsa-miR-125a/CREB5 axis
Survival: -
Supported No.:
 3
Description:

Our studies disclosed that circVAPA knockdown suppressed CRC cells cycle progression, migration, invasion and glycolysis partly by modulating miR-125a/CREB5 axis, suggesting a potential therapeutic strategy for CRC treatment.
Other information
Title:

Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis.

Journal: Cancer Cell Int
Published: 2020/4/8
PubMed ID: 32256212