circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: hsa-miR-526b
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteoblast cell line (hFOB 1.19), human osteosarcoma cell lines (MG_63, U2OS, HOS, 143B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXC2
Associated microRNA: hsa-miR-526b
Biological function: -
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 5
Description:

circPVT1, functioning as an oncogene, promotes OS cells metastasis via regulation of FOXC2 by acting as a ceRNA of miR-526b. CircPVT1/miR-526b/FOXC2 axis might be a novel target in molecular treatment of OS.
Other information
Title:

Circular RNA PVT1 promotes metastasis via regulating of miR-526b/FOXC2 signals in OS cells.

Journal: J Cell Mol Med
Published: 2020/4/7
PubMed ID: 32249539