circRNA basic information
circBase ID: hsa_circ_0001178
Name: -
Synonym: circ_0001178
Host Gene: hsa-miR-382
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HCC cells (Huh-7, Bel-7402, SNU-449, HepG2, Hep-3B cells), LO2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFA
Associated microRNA: hsa-miR-382
Biological function: promoted proliferation, migration and invasion while inhibits apoptosis
Molecular mechanism: modulate hsa-miR-382 expression negatively
Survival: -
Supported No.:
 1
Description:

Circ_0001178 was demonstrated to modulate miR-382 expression negatively. The effect of circ_0001178 on HCC tumor was rescued by miR-382 overexpression. Furthermore, vascular epithelial growth factor A (VEGFA) is identified in various cancers. Currently, VEGFA was proved to be the downstream target of miR-382.
Other information
Title:

Circ_0001178 regulates miR-382/VEGFA axis to facilitate hepatocellular carcinoma progression.

Journal: Cell Signal
Published: 2020/4/3
PubMed ID: 32240747