circRNA basic information
circBase ID: hsa_circ_0017639
Name: hsa_circ_SFMBT2
Synonym: circ_0017639
Host Gene: hsa-miR-1296-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cells (HBE), HEK-293_ cells, lung cancer cells (H460, H1650, A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1296-5p
Biological function: The regulation mechanism of circ_0017639 was demonstrated by a dual-luciferase reporter assay. We observed higher levels of circ_0017639 in DDP-resistant NSCLC samples and cells. Functionally, circ_0017639 silencing decreased tumor growth and elevated DDP sensitivityin vivoand induced apoptosis, repressed proliferation, invasion, and migration of DDP-resistant NSCLC cellsin vitro.
Molecular mechanism: circ_0001679 knockdown attenuated lung pathological changes, reduced pulmonary microvascular permeability, and suppressed inflammation in ALI mice.
Survival: -
Supported No.:
 4
Description:

In conclusion, circ_0017639 conferred DDP resistance and promoted tumor growth via elevating SIX1 expression through sequestering miR-1296-5p in NSCLC, providing a new mechanism for understanding the chemoresistance and progression of NSCLC.
Other information
Title:

Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer.

Journal: Bioengineered
Published: 2022/3/16
PubMed ID: 35287543