circRNA basic information
circBase ID: hsa_circ_0025039
Name: hsa_circ_FOXM1
Synonym: -
Host Gene: hsa-miR-614
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cell lines (H1299, H2170, A549, H1703, BEAS-2B)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: FAM83D
Associated microRNA: hsa-miR-614
Biological function: promotes proliferation
Molecular mechanism: interacting with hsa-miR-614 and thus inactivating the function of hsa-miR-614
Survival: poor
Supported No.:
 4
Description:

circFOXM1promotes NSCLC progression by interacting with miR-614 and thus inactivating the function of miR-614, which will further release the suppression of FAM83D. circFOXM1/miR-614/FAM83D regulatory network may serve as a potential therapeutic target for NSCLC patients.
Other information
Title:

circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D.

Journal: J Exp Clin Cancer Res
Published: 2020/4/2
PubMed ID: 32228656