circRNA basic information
circBase ID: -
Name: hsa_circ_LONP2
Synonym: -
Host Gene: hsa-miR-17
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC cell lines (DLD-1, HCT116, SW480)
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-17
Biological function: enhances colorectal carcinoma invasion and metastasis
Molecular mechanism: modulating the maturation and exosomal dissemination of microRNA-17
Survival: poor
Supported No.:
 1
Description:

circLONP2 acts as key metastasis-initiating molecule during CRC progression through modulating the intracellular maturation and intercellular transfer of miR-17, resulting in dissemination of metastasis-initiating ability in primary site and acceleration of metastasis formation in foreign organs. circLONP2 could serve as an effective prognostic predictor and/or novel anti-metastasis therapeutic target in CRC treatment.
Other information
Title:

CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.

Journal: Mol Cancer
Published: 2020/3/20
PubMed ID: 32188489