circRNA basic information
circBase ID: mmu_circ_0000250
Name: -
Synonym: -
Host Gene: mmu-miR-128-3p
 
 
 
Disease basic information
DO ID:
 10881
DO name: hand, foot and mouth disease
Disease details: diabetic foot ulcer
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SIRT1
Associated microRNA: mmu-miR-128-3p
Biological function: enhanced the therapeutic effect of ADSC-exosomes to promote wound healing in diabetes
Molecular mechanism: absorption of mmu-miR-128-3p and upregulation of SIRT1
Survival: -
Supported No.:
 1
Description:

mmu_circ_0000250 enhanced the therapeutic effect of ADSC-exosomes to promote wound healing in diabetes by absorption of miR-128-3p and upregulation of SIRT1. Therefore, these findings advocate targeting the mmu_circ_0000250/miR-128-3p/SIRT1 axis as a candidate therapeutic option for diabetic ulcers.
Other information
Title:

Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy.

Journal: Am J Physiol Cell Physiol
Published: 2020/3/12
PubMed ID: 32159361