circRNA basic information
circBase ID: hsa_circ_0088732
Name: hsa_circ_LCN2
Synonym: -
Host Gene: hsa-miR-661
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal glial cells (HEB), 293T cells, glioma cell lines (LN229, U87-MG, U251, A172)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: RAB3D
Associated microRNA: hsa-miR-661
Biological function: promoted cell migration, invasion, and epithelial-mesenchymal transition (EMT) while inhibits apoptosis
Molecular mechanism: negatively regulated hsa-miR-661 by targeting hsa-miR-661
Survival: -
Supported No.:
 1
Description:

We demonstrated that hsa_circ_0088732 facilitated glioma progression by sponging miR-661 to increase RAB3D expression. This study provides a theoretical basis for understanding the development and occurrence of glioma, as well as for the development of targeted drugs.
Other information
Title:

Lcn2-derived Circular RNA (hsa_circ_0088732) Inhibits Cell Apoptosis and Promotes EMT in Glioma via the miR-661/RAB3D Axis.

Journal: Front Oncol
Published: 2020/3/11
PubMed ID: 32154171