circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC66
Synonym: -
Host Gene: hsa-miR-33a-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: NSCLC cell lines (PC-9, SPC-A1, A549, H1299), human bronchial epithelial cell line(HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KPNA4
Associated microRNA: hsa-miR-33a-5p
Biological function: promoted proliferation, migration and invasion while inhibits apoptosis
Molecular mechanism: bound with hsa-miR-33a-5p in NSCLC cells.
Survival: -
Supported No.:
 1
Description:

STAT3-induced circCCDC66 upregulation accelerates NSCLC progression via miR-33a-5p/KPNA4 axis, suggesting circCCDC66 as a promising biomarker in NSCLC treatment.
Other information
Title:

STAT3-induced upregulation of circCCDC66 facilitates the progression of non-small cell lung cancer by targeting miR-33a-5p/KPNA4 axis.

Journal: Biomed Pharmacother
Published: 2020/3/11
PubMed ID: 32151944