circRNA basic information
circBase ID: -
Name: hsa_circ_DDX17
Synonym: -
Host Gene: hsa-miR-31-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal colorectal epithelial cell line (NCM460), CRC cell lines (HCT116, SW480)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: KANK1
Associated microRNA: hsa-miR-31-5p
Biological function: reduces 5-fluorouracil resistance and hinders tumorigenesis
Molecular mechanism: regulating hsa-miR-31-5p/KANK1 axis
Survival: -
Supported No.:
 2
Description:

Upregulation of circDDX17 strengthened chemosensitivity of CRC to 5-Fu and blocked CRC progression by regulating miR-31-5p/KANK1 axis, which might provide an effective treatment strategy for CRC patients.
Other information
Title:

CircDDX17 reduces 5-fluorouracil resistance and hinders tumorigenesis in colorectal cancer by regulating miR-31-5p/KANK1 axis.

Journal: Eur Rev Med Pharmacol Sci
Published: 2020/3/7
PubMed ID: 32141542