circRNA basic information
circBase ID: hsa_circ_0005075
Name: hsa_circ_EIF4G3
Synonym: circ_RNA_0005075
Host Gene: hsa-miR-431
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell lines (MNK45, AGS, MGC_803, BGC_823, HGC_27), normal gastric epithelial cell lines (GES_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: p53/EMT
Associated microRNA: hsa-miR-431
Biological function: promotes proliferation and metastasis
Molecular mechanism: inhibit the expression level of hsa-miR-431, then regulate the p53/Epithelial-mesenchymal transition axis
Survival: poor
Supported No.:
 4
Description:

The research clearly elucidated the potential role and relative regulatory mechanism of circRNA_0005075 in gastric cancer (GC) progression. Briefly, circRNA_0005075 could directly inhibit the expression level of miR-431, then regulate the p53/Epithelial-mesenchymal transition axis, and finally inhibit cell growth and metastasis in GC. Consequently, circRNA_0005075 might act as an oncogene in the GC procession, which provides a promising way for the treatment of GC.
Other information
Title:

CircRNA_0005075 suppresses carcinogenesis via regulating miR-431/p53/epithelial-mesenchymal transition axis in gastric cancer.

Journal: Cell Biochem Funct
Published: 2020/3/7
PubMed ID: 32133664