circRNA basic information
circBase ID: hsa_circ_0009910
Name: -
Synonym: Circ_0009910
Host Gene: hsa-miR-491-5p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PI3K/AKT signaling pathway
Associated microRNA: hsa-miR-491-5p
Biological function: Silenced circ_0009910 could significantly inhibit the proliferation, sphere formation, and autophagy and promoted the apoptosis of AML cells
Molecular mechanism: circ_0009910 could activate the PI3K/AKT signaling pathway by sponging hsa-miR-491-5p
Survival: -
Supported No.:
 3
Description:

Circ_0009910 could suppress the proliferation, sphere formation, and autophagy and accelerated apoptosis by modulating B4GALT5 expression and activating the PI3K/AKT signaling pathway via sponging miR-491-5p in AML cells, suggesting that circ_0009910 might be a potential biomarker for the treatment of AML.
Other information
Title:

Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.

Journal: Int J Lab Hematol
Published: 2021/10/29
PubMed ID: 34709725