circRNA basic information
circBase ID: hsa_circ_0007874
Name: hsa_circ_MTO1
Synonym: hsa_circ_104135
Host Gene: hsa-miR-9
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (HepG2, SMMC-7721, QGY-7701, SK-Hep1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: p21
Associated microRNA: hsa-miR-9
Biological function: suppress cell proliferation, migration, and invasion
Molecular mechanism: acting as the sponge of oncogenic hsa-miR-9 to promote p21 expression
Survival: better
Supported No.:
 3
Description:

CircMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR-9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients.
Other information
Title:

Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.

Journal: Hepatology
Published: 2017/5/19
PubMed ID: 28520103