circRNA basic information
circBase ID: -
Name: hsa_circ_TNPO3
Synonym: -
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human ovarian carcinoma cell lines (SKOV3, HeyA-8), normal ovarian epithelial cell line (IOSE-80)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: NEK2
Associated microRNA: hsa-miR-1299
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

circTNPO3 contributed to PTX resistance of OC cells at least partly through upregulating NEK2 expression by sponging miR-1299. circTNPO3/miR-1299/NEK2 signaling pathway might play vital roles in the tumorigenesis and chemoresistance of OC.
Other information
Title:

Circular RNA circTNPO3 Regulates Paclitaxel Resistance of Ovarian Cancer Cells by miR-1299/NEK2 Signaling Pathway.

Journal: Mol Ther Nucleic Acids
Published: 2020/8/14
PubMed ID: 32791450