circRNA basic information
circBase ID: hsa_circ_0049116
Name: hsa_circ_MUC16
Synonym: -
Host Gene: hsa-miR-199a
 
 
 
Disease basic information
DO ID:
2152
DO name: ovary epithelial cancer
Disease details: epithelial ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian cancer cell line (SKOV3)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: ATG13, Beclin1 and RUNX1
Associated microRNA: hsa-miR-199a
Biological function: promotes autophagy
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
1
Description:

circMUC16 could directly bind to miR-199a-5p and relieve suppression of target Beclin1 and RUNX1. In turn, RUNX1 elevated the expression of circMUC16 via promotion of its transcription. CircMUC16 could directly bind to ATG13 and promote its expression.

Other information
Title:

CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.

Journal: Mol Cancer
Published: 2020/3/1
PubMed ID: 32111227