circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: hsa-miR-205-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OS cell lines (Saos-2, MG63, U2OS, SW1353), normal human osteoblast cell line (hFOB 1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: c-FLIP
Associated microRNA: hsa-miR-205-5p
Biological function: Facilitates Invasion and Metastasis
Molecular mechanism: Regulating hsa-miR-205-5p/c-FLIP Axis
Survival: -
Supported No.:
 5
Description:

Our study demonstrated circPVT1 functions as a sponge for miR-205-5p to promote c-FLIP expression, thereby enhancing EMT and inducing OS invasion and metastasis in vitro, implying that circPVT1 might be a potential therapeutic target for further clinical therapy of OS.
Other information
Title:

circPVT1 Facilitates Invasion and Metastasis by Regulating miR-205-5p/c-FLIP Axis in Osteosarcoma.

Journal: Cancer Manag Res
Published: 2020/2/29
PubMed ID: 32110097