circRNA basic information
circBase ID: hsa_circ_0005035
Name: hsa_circ_IGF1R
Synonym: -
Host Gene: hsa-miR-1270
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: NSCLC cell lines (PC9, A549, Calu_1, H1299, H1975), normal human embryonic lung fibroblast cell line (MRC_5)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: VANGL2
Associated microRNA: hsa-miR-1270
Biological function: inhibits cell invasion and migration
Molecular mechanism: miRNA sponge
Survival: better
Supported No.:
 1
Description:

The overexpression of circ-IGF1R significantly inhibited the invasion and migration of the lung cancer cells. The potential network of circ-IGF1R-miR-1270-VANGL2 was preliminarily determined, and the expression patterns of miR-1270 and VANGL2 were verified in lung cancer cell lines. CONCLUSION: Circ-IGF1R may inhibit lung cancer invasion and migration through a potential network of circ-IGF1R-miR-1270-VANGL2.
Other information
Title:

Circ-IGF1R inhibits cell invasion and migration in non-small cell lung cancer.

Journal: Thorac Cancer
Published: 2020/2/29
PubMed ID: 32107851