circRNA basic information
circBase ID: hsa_circ_0004287
Name: hsa_circ_MALAT1
Synonym: -
Host Gene: hsa-miR-6887-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293T, human HCC cell lines (Hep3B, Huh7, HepG2, SMMC_7721)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PAX5
Associated microRNA: hsa-miR-6887-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circMALAT1 functions as a brake in ribosomes to retard PAX5 mRNA translation and promote CSCs self-renewal by forming an unprecedented ternary complex with both ribosomes and mRNA.
Other information
Title:

Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells.

Journal: Adv Sci (Weinh)
Published: 2020/2/27
PubMed ID: 32099751