circRNA basic information
circBase ID: hsa_circ_0003159
Name: hsa_circ_CACNA2D1
Synonym: -
Host Gene: hsa-miR-223-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human gastric mucosal epithelial cells (GES-1), GC cell lines (NUGC-3, AGS, HS-746T, N87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NDRG1
Associated microRNA: hsa-miR-223-3p
Biological function: suppressed proliferation, migration, invasion and xenograft tumor growth but promoted apoptosis
Molecular mechanism: decreasing hsa-miR-223-3p and increasing NDRG1
Survival: better
Supported No.:
 3
Description:

Hsa_circ_0003159 suppressed proliferation, migration, invasion and xenograft tumor growth but promoted apoptosis by decreasing miR-223-3p and increasing NDRG1 in GC, indicating a novel target for treatment of GC.
Other information
Title:

Hsa_circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis.

Journal: Cancer Cell Int
Published: 2020/2/27
PubMed ID: 32099530