circRNA basic information
circBase ID: hsa_circ_0006282
Name: hsa_circ_TCEB1
Synonym: -
Host Gene: hsa-miR-155
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GC cell line (BGC-823, MKN-45, AGS, HGC-27), human gastric mucosal epithelial immortalized cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FBXO22
Associated microRNA: hsa-miR-155
Biological function: Promotes Cell Proliferation and Migration
Molecular mechanism: Sponging hsa-miR-155 to Upregulate the Expression of FBXO22
Survival: poor
Supported No.:
 3
Description:

Our findings indicated that over-expression of circ_0006282 down_regulated miR-155 to activate the expression of FBXO22, thus promoting proliferation and metastasis of GC cells, which provides a promising therapeutic target for GC treatment.
Other information
Title:

Circular RNA circ_0006282 Contributes to the Progression of Gastric Cancer by Sponging miR-155 to Upregulate the Expression of FBXO22.

Journal: Onco Targets Ther
Published: 2020/2/27
PubMed ID: 32099403